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June 20, 1896


Author Affiliations

Demonstrator of Physiology and Lecturer on the History of Medicine in the Medical Department of the University of Texas.

JAMA. 1896;XXVI(25):1219-1222. doi:10.1001/jama.1896.02430770021001g

Recent literature concerning antipyretics and analgesics has brought to the notice of the profession several new drugs, among which apolysin seems to occupy a prominent place. Through the courtesy of a new York drug firm that kindly furnished me with a considerable amount of the new medicament, I have been enabled to conduct a series of experiments in the physiologic laboratory of the University of Texas, at Galveston, the results of which I shall endeavor to embody in this brief report.

Apolysin is a substance closely related to phenacetin. Like the latter drug apolysin contains paraphenetidin. In phenacetin, however, the paraphenetidin of the amide group (NH2) one atom of hydrogen is replaced by an acetic acid radical; while in apolysin the atom of hydrogen of the paraphenetidin of the amide group is substituted by a citric acid radical. It may be said in this connection, that a combination of

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