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October 27, 1906


JAMA. 1906;XLVII(17):1383-1384. doi:10.1001/jama.1906.02520170047012

The peculiar type of periodic respiration first accurately described by the great Irish clinicians has long been known to the profession as a not infrequent accompaniment of certain forms of uncompensated heart disease and of cerebral compression. The sign, per se, so far has not been of any great diagnostic significance, though from the standpoint of prognosis it has usually been regarded as a distinctly unfavorable portent, often unjustly. It has been universally held that the mechanism of the sign, though obscure, was doubtless the same in all cases, no matter what the character of the primary disease. The recent work of Eyster1 is of interest in this connection, as it shows that the form of Cheyne-Stokes breathing which accompanies cerebral compression differs from that which occurs in connection with cardiac and renal diseases. In Cheyne-Stokes respiration due to cerebral compression, the period of respiratory activity is associated with

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