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Article
July 9, 1904

THE PRECIPITINS.

JAMA. 1904;XLIII(2):126. doi:10.1001/jama.1904.02500020040005
Abstract

The unexampled activity displayed in the study of the reaction products which are obtained when organic substances of the most diverse character are injected into the animal body, has already borne fruit in several ways. Among the many interesting bodies found in the "antisera" are the substances known as precipitins. It will be remembered that these were first discovered in 1897 by Kraus, who found that the serum of goats that had been treated with cholera bacteria, when added to the germ-free filtrate of cholera cultures, produced a precipitate, while normal serum, added to the same filtrate, left the latter entirely clear. The strict specificity of this reaction has been maintained by Kraus and other observers, but has lately been questioned by Norris1 from the results of an extended research. This observer concludes that the bacterial precipitins can not be considered specific in the strict sense, although, like the

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