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A very interesting development of our knowledge of the effect of the various preparations of the suprarenal gland has been the confirmation from a number of observers in different countries of the fact that the use of considerable quantities, in animals at least, produces arterial degeneration. It is pointed out as a triumph of experimental pathology that at last we are in the position to be able to produce degeneration of arteries at will for purposes of study. It is rather disquieting news, however, for those who have been prescribing the remedy in considerable doses for some time and still more for those who have advised its employment over prolonged periods for the treatment of nasal conditions. The use of various preparations of the suprarenal gland in powder form for local applications in the nose has not been confined to physicians' hands; patients have been given powder blowers and have
A DANGER IN ORGANOTHERAPY.. JAMA. 1906;XLVII(19):1568. doi:10.1001/jama.1906.02520190048008