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I have proven in my book on "The causal Treatment of Tuberculosis," (Leipzig, 1894) that it was possible to heal, perfectly, tuberculosis of guinea pigs and man by certain products of tubercle bacilli, advancing the theory that this effect was obtained by a secretion product of these organisms, found mostly in the fluid portion of the cultures. If this opinion is a correct one the healing process in this disease would find an analogue in a great series of well known biologic processes, such as uremia, cholemia, etc. It must be acknowledged as a general law that every organism forms substances poisonous to itself, if they are not secreted or separated from the body by the action of glandular secretion as by the kidneys, liver, etc.
The first substance having this property of destroying tubercle bacilli, I obtained from the whole culture, and gave it the name tuberculocidin (or tubercle-killer).
KLEBS E. ON HEALING AND IMMUNIZING SUBSTANCES OF TUBERCLE CULTURES.. JAMA. 1896;XXVII(4):176-181. doi:10.1001/jama.1896.02430820004002