For a number of years acetozone has been vigorously pushed in the treatment of typhoid fever, the manufacturers making the following claims:
A greater freedom from intestinal disturbances such as characteristic odor of stool, diarrhea, tympanites, hemorrhage, perforation, peritonitis.
A diminution of the toxemia, and the consequent improvement in physical and mental condition.
The return to normal temperature more quickly.
A modification of the course, severity, and type.
Complications less frequent.
Relapses less frequent.
Recovery more prompt and certain.
We will see how far these claims are substantiated in a short series of 10 cases in which records have been kept; bearing in mind that the series is too short to indicate very much either way. All the patients in the series were treated by hydrotherapy with a milk diet. The acetozone solution contained from 15 to 20 grains to the quart, and was administered freely according to directions.
HUMISTON R. ACETOZONE IN TYPHOID FEVER.. JAMA. 1906;XLVII(20):1651-1652. doi:10.1001/jama.1906.25210200047002