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Article
November 24, 1906

A PATHOLOGIC STUDY OF SEVEN CASES OF PARALYSIS WITHOUT GROSS ANATOMIC CHANGEIN RELATION TO THE CAUSE OR CAUSES OF UREMIC HEMIPLEGIA.

Author Affiliations

Neurologist to the Howard Hospital. PHILADELPHIA.

From the Philadelphia General Hospital and from the Department of Neurology and Laboratory of Neuropathology, University of Pennsylvania.

JAMA. 1906;XLVII(21):1705-1706. doi:10.1001/jama.1906.25210210013001c
Abstract

The following report embodies the results of a pathologic study of.seven cases of paralysis associated with chronic kidney disease, such as are not infrequently regarded as of uremic origin, in which no gross anatomic change was found to account for the paralysis. These cases were studied with a view of determining, if possible, the cause, or causes, of paralysis, as we observe it, in persons brought to the hospital who lived under observation but a short time, and who present paralysis which can hot be attributed to cerebral hemorrhage, with which the evidences of grave nephritis are often associated.

In Cases 1, 2, 3, 4, 5 and 7, the findings warranted a diagnosis of cerebral syphilis, and in Case 6 the lesion, although not entirely characteristic of syphilis, pointed to a similar diagnosis. In this case there was much arterial change, and the perivascular spaces of the paracentral cortex were

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