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Article
December 29, 1906

THE OPSONIC INDEX IN TYPHOID FEVER.A PRELIMINARY REPORT.

Author Affiliations

CHICAGO.

From the Memorial Institute for Infectious Diseases, Chicago.

JAMA. 1906;XLVII(26):2159. doi:10.1001/jama.1906.25210260029002d

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Abstract

From a study of 33 cases of typhoid fever in which one or more estimations of the opsonic index were made, certain broad conclusions relative to the index in this disease may be deduced.

It has been demonstrated that there occurs during a typhoid infection a marked rise in the opsonic index; that the index varies from day to day; that there is early in the disease a high index; as the temperature decreases this appears to fall and to rise again as convalescence approaches, but more cases must be studied before any final conclusions may be drawn.

That the high index is due to the presence of opsonin and not to the incorporation by the leucocytes of clumps of bacilli resulting from agglutination is demonstrated by a comparison of the number of phagocytes in the normal as compared with that of the patient's specimen. In many cases the index

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