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January 5, 1907


Author Affiliations

Associate in Nervous and Mental Diseases, Jefferson Medical College; Examiner of the Insane at the Philadelphia General Hospital. PHILADELPHIA.

JAMA. 1907;XLVIII(1):38-42. doi:10.1001/jama.1907.25220270038001g

The most recent researches in the domain of physiologic chemistry lead to the view that migraine finds its logical explanation in a pathologic metabolism and that the immediate cause of a migrainic attack lies in auto-intoxication. Whether it is uric acid, as championed by Haig, or special ferment or ptomain, as advocated by Friesser, it is not completely elucidated. The fact is, that in the majority of cases, if not in all, there is an element of gastrointestinal disorder. A priori one can say than an attack of migraine suggests a cerebral poisoning. The headache and other cerebral symptoms observed in a migrainic attack are analogous to the same symptoms in diseases of the meninges and tumors of the brain. It is possible that in migraine the primary cause is of a cerebral nature and the digestive disturbances are brought on by the condition of the brain. Practically speaking, there

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