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January 12, 1907


Author Affiliations

Captain, Assistant-Surgeon, United States Army, now stationed at Malabang, Mindanao, P. I.

JAMA. 1907;XLVIII(2):133-136. doi:10.1001/jama.1907.25220280045001j

The observations here recorded are in sequence of others formerly made on this subject at Fort Reno, O. T.1

In that series the antitoxin was developed by inoculating rabbits with defibrinated blood of patients harboring the parasite of tertian malaria (Plasmodium vivax) or by the bites of mosquitoes infected with that protozoön. Four patients in that series were treated with the hypodermic injections of defibrinated blood drawn from inoculated rabbits, one with serum, two with desiccated serum in salt solution and two with desiccated erythrocytes in salt solution. The injections of defibrinated blood and of desiccated erythrocytes and one injection of desiccated serum were followed by more or less prompt recovery. The undesiccated serum and serum in salt solution had been given in such small quantities (0.75 gm. and 0.50 gm., respectively) that no result could reasonably have been expected.

In the present series the animals employed were monkeys,

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