Undoubtedly syphilis is quite capable of producing, and does produce, in certain instances, arteriosclerosis, but the existing relationship is somewhat obscure.
There is no disease in the whole category of diseases which brings to view so many and varied symptoms as syphilis, and it would be singular, indeed, if it did not enter as a causative factor in the production of arteriosclerosis when taking into consideration its known tendency to produce sclerosis in various organs.
That syphilitic arteritis and endarteritis do occur not infrequently, and that, too, early during the history of this disease, is recognized as a fact both by clinician and pathologist; furthermore, there is probably no disease which is so amenable to treatment, if such be instituted prior to pathologic changes which are not absolutely beyond repair. It will perhaps ever remain an
DRENNEN CT. ARTERIOSCLEROSIS OF SYPHILITIC ORIGIN.. JAMA. 1904;XLIII(11):729. doi:10.1001/jama.1904.92500110001e