It is said that acetone in small quantity appears normally in the urine, but the amount becomes pathologic at times in connection especially with certain disorders of metabolism, of which diabetes is the most familiar example. Of itself it gives rise to no symptoms, but its presence is often associated with that of other substances, especially diacetic acid and beta-oxybutyric acid, and when abnormal phenomena make their appearance they are probably due to the latter. All of these are probably the results of some derangement in fat-metabolism. The development of stupor, followed by coma and death, after operations on patients, particularly diabetics presenting acetonuria, has been observed rather frequently, while the occurrence of acid intoxication under various conditions had been earlier recognized.
Drs. E. G. Brackett, J. S. Stone and H. C. Low1 report a group of cases presenting the following symptom-complex: Vomiting, associated with collapse; weak and rapid
ACID INTOXICATION.. JAMA. 1904;XLIII(11):740. doi:10.1001/jama.1904.02500110034006