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September 10, 1904


JAMA. 1904;XLIII(11):742. doi:10.1001/jama.1904.02500110036011

A recent communication1 from Maragliano's clinic at Genoa calls attention to the constancy of a great increase in the number of red corpuscles in case of a small, rather torpid tuberculous focus somewhere in the body. These findings suggested the possibility that the minute amounts of antibodies, generated in the course of such an inactive process, might be the cause of the hyperglobulia observed. This assumption was sustained by the constantly positive findings when guinea-pigs were injected with small, repeated doses of tuberculin, the result invariably being a pronounced hyperglobulia. These findings further suggested in turn the possible application of the measure in treatment of all kinds of anemia and chlorosis, not necessarily of a tuberculous character. Tuberculin in the minute, "refractory" doses employed is harmless, and is being given a thorough trial now in the clinic; the results seem to be promising, although it is too early for

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