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Article
March 2, 1907

THE NATURE OF HERPES SIMPLEX, WITH A CONSIDERATION OF ITS DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE IN VARIOUS INFECTIOUS DISEASES.

Author Affiliations

Professor of Dermatology and Eruptive Infectious Diseases in the Philadelphia Polyclinic and College for Graduates in Medicine. PHILADELPHIA.

JAMA. 1907;XLVIII(9):746-750. doi:10.1001/jama.1907.25220350004001a
Abstract

There are many features of resemblance between simple herpes and herpes zoster, but there are also strong points of dissimilarity. In extreme cases of herpes, particularly about the face, it is sometimes difficult to distinguish between the zoster and simple forms. The clusters of firm vesicles on an erythematous base are identical in both. Histologically, the lesions in the skin and those in the affected nerve structures are practically the same in the two varieties. Thus far simple herpes might almost be regarded as a circumscribed abortive zoster; but there are other differentiating clinical features. The most important is the tendency to recurrence in simple herpes, contrasted with such a rarity of second attacks in herpes zoster as almost to suggest an immunity conferred. Indeed, second attacks of true zoster are no more common than second attacks of measles or scarlet fever. Head and Campbell met with only four cases

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