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March 2, 1907


Author Affiliations


JAMA. 1907;XLVIII(9):750-754. doi:10.1001/jama.1907.25220350008001b

OPTIC ATROPHY.  The first anatomic demonstration of the pressure effects on the optic nerve of sclerosed vessels at the base of the brain was made by Michel1 in 1877. This case is unique inasmuch as the resulting ocular disturbance was bilateral choked disc which Michel explained by assuming pressure on the lymph spaces of the optic nerve.From time to time since the publication of this case others have appeared in literature, but it remained for Otto2 in 1893 to present a large enough series of cases to permit of conclusions being drawn as to the nature of the gross and minute anatomic changes and of their possible clinical manifestations. In 11 of this group of 20 autopsies there were more or less marked changes in the form of the optic nerve consisting of a flattening and a subsequent atrophy of the nerve fibers, primarily centrally situated but

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