March 23, 1907


JAMA. 1907;XLVIII(12):1035. doi:10.1001/jama.1907.02520380051010

The case reported by Corrigan last week,1 in which methylene blue was given to a woman during the last six months of her pregnancy, is of interest both in regard to the composition of the liquor amnii and the action of the kidneys of the fetus in utero. In the amniotic fluid no coloring matter was noticed, while the urine passed after birth by the infant contained methylene blue. Similar observations have been made by others. Thus Gusserow administered benzoate of soda to the mother and it appeared as hippuric acid in the urine of the newborn child. Schaller in 1899 gave phloridzin and examined the fetal urine and amniotic fluid at various periods of pregnancy. He found that there is no regular secretion and periodic excretion of fetal urine even near to term, but that fetal renal activity usually begins when the process of labor induces changes in

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