In considering the diseases of the gall bladder it is necessary to recognize that this viscus constitutes one of the most vulnerable points for infection in the abdominal cavity, and in this respect is analogous to the fallopian tube and the appendix.
A difference is noted in comparison with the appendix in that in the latter structure infective agents are more or less constantly present in its lumen normally, while the gall bladder is generally free from microorganisms; furthermore, infection of the gall bladder concerns itself more with the contents than the walls, the sterile bile becoming a culture medium for microorganisms, while in appendix infection the coats are more prominently involved.
BIERRING WL. ETIOLOGY OF CHOLECYSTITIS AND CHOLELITHIASIS.. JAMA. 1904;XLIII(16):1099-1102. doi:10.1001/jama.1904.92500160001