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Article
October 15, 1904

EXPERIMENTALLY PRODUCED GENUINE EPITHELIAL METAPLASIA IN THE STOMACHAND THE RELATIONS OF EPITHELIAL METAPLASIA TO CARCINOMA, AS DEMONSTRATED BY CASES REPORTED IN THE LITERATURE.

JAMA. 1904;XLIII(16):1129-1140. doi:10.1001/jama.1904.92500160001h
Abstract

As the observations on epithelial metaplasia to be reported in this paper were made in a series of experiments on the stomach of rabbits, undertaken for the purpose of studying the relations between mechanical irritation and development of carcinoma, I think it necessary to state this fact, merely to show under what circumstances the findings were made. My views concerning the rôle which mechanical irritations play in the etiology of carcinoma, and how those views have been formed, have been fully explained in former writings, and I can, therefore, refer the reader to them, in order to prevent repetitions, which would make this article too extensive.1

Some observations of importance have been made which I do not report, because they need corroboration, but they certainly encourage further efforts along the same lines.

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