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April 6, 1907


JAMA. 1907;XLVIII(14):1186. doi:10.1001/jama.1907.02520400038004

The importance of discovering a definite method by which can be produced experimentally ulcers in the stomach that in every way are analogous to genuine human gastric ulcer needs no emphasis. The prevention and the healing of human ulcers would thereby unquestionably be promoted in various ways. Recently reports have been made of results in this field of experimentation which indicate that noteworthy progress is being achieved. Thus Turck1 has shown that by feeding dogs for variable periods with large quantities of cultures of colon bacilli ulcers not unlike round or peptic ulcer in man may be produced in the stomach and duodenum.

The exact mechanism whereby ulcers are produced under these conditions has not been worked out, but the indications point to a combination of local and general disturbances. It would seem that the method, if found by other investigators to give reliable and constant results, will prove

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