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April 13, 1907


Author Affiliations

Instructor in Neuropathology and Electro-therapeutics at the University of Pennsylvania; Assistant Neurologist to the Philadelphia General Hospital. PHILADELPHIA.

From the Department of Neurology and the Laboratory of Neuropathology of the University of Pennsylvania.

JAMA. 1907;XLVIII(15):1230-1239. doi:10.1001/jama.1907.25220410006001b

The subject of the pathology of paralysis agitans is one on which few physicians have definite ideas, and those who have differ widely from each other. It is obvious that so long as the nature of this disease is in controversy and obscurity the treatment must be imperfect, changeable and unfortunately inefficient. Numerous investigations with the idea of clearing up this problem have but added to its complexity by suggesting new hypotheses and unexplored fields for reasearch.

The clinical picture of paralysis agitans is so clear cut and typical, the course of the disease so unchangeable and progressive that it certainly suggests an organic basis. To classify it as a neurosis is begging the question and explains nothing, while it would be distinctly harmful if it hindered further search for the real pathology.

SUMMARY OF LITERATURE.  In order to define the present status of our knowledge of the subject, it

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