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The probability of there being some relationship between syphilis and aneurism has long been recognized. In 1886 Flint wrote in his Practice of Medicine (sixth edition): "As bearing on the diagnosis, it may be here stated that aortic aneurism is a rare event under 40 years of age, and that syphilis is often a remote cause." Since then we have learned that aortic aneurism under 40 is not an especially rare event, relatively speaking. and that syphilis may maintain a much closer relation to aortic aneurism than that of a remote cause. Among the various facts that have served to direct and fasten attention to the relationship between syphilis and aneurism may be mentioned especially the occurrence of aortic aneurism in notorious syphilitics at a relatively early age—25 to 45—which, of course, does not harmonize perfectly with the generally accepted views as to the rôle of ordinary arteriosclerosis in the
SYPHILITIC AORTITIS AND ANEURISM.. JAMA. 1904;XLIII(19):1396-1397. doi:10.1001/jama.1904.02500190048003