The first requisite to an adequate discussion of the prevention of gout is a clear view of its causation.
The one thing which, it seems to me, emerges clearly from the seething caldron of the clinical and chemical researches of the past fifty years is that whatever be the cause of gout it is not uric acid. The first step, then, is to rid our minds of the delusion, that any means which are to cure gout, must be directed toward either increasing or diminishing the formation or promoting the elimination of uric acid or any of its precedents.
I fear that to many this position will appear radical to the verge of foolhardiness, but it is the one which appears most rational and tenable to me, and I will, therefore, proceed to sketch very briefly its basis and its bearing on this most important problem, with no further apology,
HUTCHINSON W. THE URIC-ACID DELUSION AND THE PREVENTION OF GOUT.. JAMA. 1904;XLIII(23):1685–1690. doi:10.1001/jama.1904.92500230001d