Very soon after the existence of infantile scurvy as a clinical entity was established, it was recognized that hematuria was a not uncommon symptom. All writers on the subject refer to hematuria as one of the symptoms, but very few lay any stress on it or emphasize its importance. Holt1 says that it is seen in about 5 per cent. of the cases while Rotch2 says that it has been noticed in a certain number and that it is well to examine the urine when this disease is suspected.
While all writers mention hematuria as one of the symptoms of scurvy, most of them give the impression that it is rather an unusual symptom and certainly not an important one. Very few call attention to the fact that it may be the earliest symptom, and hence, for a time, the only symptom. Holt1 says that in rare cases hematuria has
MORSE JL. HEMATURIA AS THE EARLIEST OR ONLY SYMPTOM OF INFANTILE SCURVY.. JAMA. 1904;XLIII(25):1847-1849. doi:10.1001/jama.1904.92500250002d