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It is generally taught that ether is less toxic than chloroform, that it is less depressing in its action on the heart, and that the selective action of ether on the respiratory center is more manifest. A series of classroom experiments led us to doubt the truth of these views, and the present research was undertaken in the hope of clearing up, if possible, some of these questions. The following series of experiments were performed:
Ether was injected into the jugular vein, the blood pressure being recorded in the carotid artery, the vagus nerves being intact.
Ether was injected into the jugular vein, both vagi being cut.
Ether was injected into the carotid artery, the other carotid being used for recording the blood pressure, the vagi being intact.
Ether was injected into the carotid artery, the vagi being cut.
Ether was injected subcutaneously.
Chloroform was injected into the jugular vein,
MUEHLBERG W, KRAMER SP. THE ACTION OF TOXIC DOSES OF ETHER AND THE INFLUENCE OF AMYL NITRITE THEREON.. JAMA. 1907;XLVIII(25):2093-2098. doi:10.1001/jama.1907.25220510011001d