At the Seventh French Medical Congress recently held at Paris Professor Chantemesse1 reported the results obtained during three and one half years in the treatment of 545 cases of typhoid fever with serum obtained from a horse rendered immune by injections of soluble typhoid toxin. There were among these cases 22 deaths (4 per cent.), while in the hospitals of Paris generally there were among 3,199 cases from April 1, 1901, to Oct. 1, 1904, 581 deaths (18 per cent.) It was found that intestinal perforation was not diminished as a result of serum-treatment to the same extent as were other causes of fatal termination. As the intestinal lesions are the initial alterations, it is important to inject the serum early. Perforation of the bowel was observed in no case treated with serum during the first week of the disease. Cold baths are given when the temperature is high.
THE SERUM-TREATMENT OF TYPHOID FEVER.. JAMA. 1904;XLIII(25):1876. doi:10.1001/jama.1904.02500250046009