There is probably no group of diseases regarding which more confusion has existed than the diseases of the blood and of the blood-forming organs. The relation which exists between the different forms of leukemia, and the relations which this disease bears to chloroma and to lymphosarcoma, have given rise to endless discussion, much of which has been profitless and even rendered confusion more confounded on account of the lack of definiteness in the use of terms. In recent years, much light has been shed on the dark places by more careful study of the bone-marrow, and by more minute histologic examination, but much yet remains to be cleared up.
The question of the relation of the peculiar disease known as chloroma to the leukemias is an old one, and a close relationship has been suspected for some time. In a recent study of a case of chloroma, Dock and Warthin
CHLOROMA AND ITS RELATION TO LEUKEMIA.. JAMA. 1904;XLIII(27):2039. doi:10.1001/jama.1904.02500270033007