January 7, 1905


JAMA. 1905;XLIV(1):41. doi:10.1001/jama.1905.02500280047005

Although it is now ten years since Baumann isolated the active principle of the thyroid gland, and since Roos demonstrated that this iodin-containing body accomplished the chief functions of the thyroid, if not all of them, yet it has not to this day been settled whether thyroidin acts by neutralizing toxic products of metabolism or by furnishing some stimulus necessary for proper metabolism. Much evidence has accumulated, however, to lend support to the view that neutralization of toxic substances is an important function of the thyroid, whether its sole function or not. Of particular interest is the evidence secured through the successful treatment of exophthalmic goiter on principles suggested by the antitoxic theory of thyroid function. From the results of many experimental and clinical observations, it has been well established that the symptoms of exophthalmic goiter are largely due to a poisoning by products of thyroid metabolism, although the cause

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