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November 29, 1890


JAMA. 1890;XV(22):789-794. doi:10.1001/jama.1890.02410480017003

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Report of an Experimental Investigation OF THE ACTION OF CHLOROFORM AND Ether.  —At the annual meeting of the British Medical Association held at Birmingham, July, 1890, Dr. John A. Williams presented in the Section on Medicine, a report upon this subject, and closed his paper with an extended summary of conclusions as follows, as reported in the Brit. Med. Journal, Oct. 25.1. During chloroform anæsthesia the blood pressure is lowered and the heart's action is weakened.2. Dilatation of the heart occurs to an appreciable extent, even when chloroform is administered gently, mixed with abundance of air (under 4 per cent. of chloroform vapor in the air).3. Dilatation may occur even before the conjunctival reflex is abolished.4. The dilatation affects all parts of the heart more or less — the left side as well as the right. It is not due to changes in the pulmonary circuit.

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