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March 18, 1905


JAMA. 1905;XLIV(11):877-879. doi:10.1001/jama.1905.02500380041006


Having considered the general physical and chemical properties of uric acid, we are now prepared to review the opinions bearing on the form in which uric acid and the urates exist in the urine on the one hand, and in the tissue juices and the blood on the other. More than ordinary interest attaches to the conditions through which it is held in solution in the body, and a great deal of work has been done to determine the form in which it is precipitated in gouty deposits and in urinary sediments and concrements. Much study has been devoted to the factors which determine such precipitation and sedimentation.

In fresh, normal urine, the uric acid and urates are always in solution, but on standing a sediment tends to form. This may be either a red, sand-like crystalline powder, which collects on the bottom or on the sides of the

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