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Article
March 21, 1891

A COMPARISON BETWEEN SALICIN AND THE SALICYLATE OF SODIUM.

JAMA. 1891;XVI(12):415. doi:10.1001/jama.1891.02410640019006

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Abstract

Dr. Alexander Haig has recently read a paper before the Medical and Chirurgical Society of London on the comparative merits of these two drugs in the treatment of acute articular rheumatism. He bases his comparison on the relative power of the two drugs to excrete, or to stimulate the excretion of, uric acid. He has found that the salicylate of sodium has about thirteen times the excretory potency of the other drug, and he thinks he has seen that their power to interfere with the course of the disease has been approximately identical with their liberation of uric acid. His contention is that all those plans of treatment of acute rheumatism that have proved beneficial have been so in an exact proportion to their uric acid secerning power. According to Dr. Haig's reasoning, acute rheumatism is caused by the presence of uric acid, primarily, in the blood and that being

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