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Because of their scientific importance and certain practical features the serum-precipitins should receive something more than the incidental mention which has been given them under agglutination and in other chapters.In 1897 Kraus discovered that bouillon cultures of the organisms of typhoid, cholera and plague, from which the bacteria had been removed by filtration, would Bacterial cause precipitates when mixed with their Precipitins. respective antiserums. The reaction is specific. As stated later, however, this specificity holds only when those quantitative relationships are observed which were found so essential for the agglutination test. The precipitins of Kraus are the bacterial precipitins. He proposed their use for the identification of micro-organisms. If, for example, one has in hand a culture which he suspects to be that of the typhoid bacillus, it may be grown in a liquid medium, the cells removed by filtration, and the filtrate mixed with a
Special ArticleIMMUNITY.. JAMA. 1905;XLIV(15):1193-1195. doi:10.1001/jama.1905.02500420037003