There is probably no disease which is so characteristic clinically and so devoid of characteristics pathologically as hemophilia. The hereditary character of the affection, the peculiar transmission through the female line to the male descendants, the tendency to continued hemorrhage from slight injury or spontaneously, the subcutaneous hemorrhages, and the acute joint lesions present a clinical picture which can hardly be confused with any other condition. It is true that in rare cases, such as those in which kidney hemorrhages are the only symptom, the diagnosis is not always so clear, but these are the exception.
The underlying cause of this interesting condition, which has been recently studied by Sahli,1 has been a source of investigation and discussion since the disease was first discovered. The anatomic findings in fatal cases have been so inconstant and so uncharacteristic that either a new theory or a modification of an old one
THE ESSENTIAL LESION IN HEMOPHILIA.. JAMA. 1905;XLIV(15):1198-1199. doi:10.1001/jama.1905.02500420042006