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Article
March 5, 1898

APYRETIC TYPHOID FEVER.

JAMA. 1898;XXX(10):559. doi:10.1001/jama.1898.02440620047005

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Abstract

It is an interesting fact in clinical medicine that every infectious disease which attacks human beings in the vast majority of cases results in producing a more or less constant rise in bodily temperature. One would suppose that the poisons of one infection might irritate the heat centers in such a way as to cause an increased generation of heat, while other poisons would depress them to such an extent, or would so seriously interfere with oxidation processes in the body, that instead of the temperature rising above normal it would fall below it. It is true that in a certain number of cases where the infection is particularly malignant, and where the individual seems peculiarly susceptible, fall of temperature does follow the infection, the patient immediately passing into a condition of profound toxemia with symptoms resembling collapse, but these instances are so rare as to be practically curiosities in

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