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May 2, 1891


JAMA. 1891;XVI(18):634-636. doi:10.1001/jama.1891.02410700022005

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These have been overstated by some with the same precipitous spirit which others have displayed in their anticipation of its power for good. In the many control observations tuberculin has not been found to injure any non-tubercular person beyond the inconvenience of the febrile reaction. In tubercular subjects, however, the reaction may be alarming in severity and lead to delirium, coma, angina pectoris (Jacobi) collapse and even death. At least one death (Janisch of Innsbruck) has thus been caused by acute tuberculin-poisoning. This danger is more or less in proportion to the intensity of the reaction and it is now universally conceded, that by sufficient caution in beginning with minute quantities and increasing only slowly in dose, such acute dangers can be avoided with certainty. But apart from the possibility of acute poisoning, other accidents have been observed. The local reaction consists in intense congestion around the tubercular focus, effusion

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