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June 17, 1905

Special ArticleIMMUNITY.

JAMA. 1905;XLIV(24):1928-1930. doi:10.1001/jama.1905.02500510036002


THE SIDE-CHAIN THEORY OF EHRLICH AND ITS RELATION TO THE THEORY OF PHAGOCYTOSIS.  Ehrlich,1 in 1885, before the discovery of toxins and antitoxins, before there was any knowledge as to the real nature of immunity, and before he had become actively interested in its study, published a small volume on the "Oxygen Requirements of the Body." Herein the belief was expressed that the assimilation of foods by cells is accomplished only after chemical union has taken place between the food substance and some constituent of cellular protoplasm. It is not the understanding that assimilation is at an end, however, when this union has occurred, for certain molecules of complex chemical nature and of great size must be split up into simpler substances before they enter into the composition of protoplasm. Therefore, the cell constituent which combines with the nutritious molecule serves only as a link to bring

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