There was a time when the febrile process, as well as the inflammatory one, was considered a distinct morbid entity, with more or less constant and characteristic features; and, although we are not yet cognizant of the intimate nature of the reactions that take place under such conditions, it is appreciated that they are due to the operation of a number of factors of varying kind and degree; so that the resulting phenomena may be correspondingly variable. It has further been maintained, as Liebermeister1 points out in a philosophic communication on the subject of antipyresis, that the course of the febrile process should not be interfered with, but that it should rather be supported. It has, however, been learned more recently that while there are some conditions in which this precept is a good one to follow, there are others in which it is advisable to control the fever.
PYREXIA AND ANTIPYRESIS.. JAMA. 1900;XXXV(2):95-96. doi:10.1001/jama.1900.02460280031005