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Article
July 14, 1900

HEMORRHAGIC NEPHRITIS THE EXPRESSION OF GENERAL INFECTION.

JAMA. 1900;XXXV(2):99. doi:10.1001/jama.1900.02460280035012
Abstract

Instructive cases have been described recently by Holst1 of acute hemorrhagic nephritis as the principal manifestation of a general microbic infection of the blood. In one case the disease lasted nearly eight months and was in reality a streptococcus bacteriemia—streptococci being found in the blood and elsewhere—but appeared clinically as a hemorrhagic nephritis of a febrile type. In the second case, the renal symptoms were associated with evidences of acute endocarditis. Staphylococcus albus was grown from the blood during life, and after death from the excrescences upon the mitral valve. A third case was observed for a time. Here there existed a fully-compensated heart lesion of some duration, but which rather suddenly became complicated with symptoms of acute nephritis. While under observation, the urine, secured under aseptic conditions, contained micrococcal masses that proved to be staphylococcus albus in pure culture. Holst emphasizes especially these two points: 1. Acute hemorrhagic

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