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July 28, 1900


JAMA. 1900;XXXV(4):238-239. doi:10.1001/jama.1900.02460300040015

One of the latest developments in pathology is the discovery and study of cytotoxins of animal origin produced by the injection of an animal with the various cells of another animal of a different species. The serum of the first animal gradually becomes toxic for the corresponding cells of the second animal. In this way there have been produced hemotoxins—substances that destroy red blood-corpuscles—leucotoxins—substances destructive of ceucocytes—spermotoxins, destructive of spermatozoa, etc. Some reference has been made in these columns to these cytotoxic serums and their actions.1 The fertile Metchnikoff sees in these demonstrations a number of far-reaching possibilities, and has busied himself in working out their application to human pathology and therapy. The success of serum treatment in diphtheria serves as an encouragement to work of this kind. This is the day of serums and of ferments, and everywhere investigators are engaged in preparing serums for the treatment of

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