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August 25, 1900


JAMA. 1900;XXXV(8):478. doi:10.1001/jama.1900.24620340014001f

In dealing with the influence of any etiologic factors, these factors must be considered in connection with the organism on which they act—the latter in its constitutional aspects and in regard to its condition at the time the chemical factor begins its action. The local condition of the parts affected must likewise be taken into consideration. As the gums at times take upon themselves the function of excretion, they are peculiarly apt to be affected by chemical action. Prominent among the agents which produce effects on the gum and the other transitory structures are the alteratives and tonics. Arsenic, gold, iodin, iron, mercury, brass, lead, copper and phosphorus all produce, by their excretion through the gums, conditions of edema, which are predisposing factors to interstitial gingivitis. Arsenic, gold, iron, phosphorus and mercury all set up an inflammatory condition. Among the vegetable alteratives having a like action; colchicum, guaiac, salicylic acid,

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