This may be a matter of considerable ease, or one of extreme difficulty, depending on the stage of the disease and the nature of the pathologic conditions. Let us first consider its diagnosis at an early stage. Tuberculosis is an infection, and as is the rule with infections, it occasions a rise of temperature even at its incipiency. Except very rarely, when the infection is violent or the disease assumes the acute pneumonic type, the elevation of temperature is slight, and may even escape detection. If the thermometer shows a constant elevation ranging between 99.5 and 100.5 F. it is in a suspected case strongly suggestive of tuberculous infection. The temperature should be registered not merely night and morning, but four or five times daily, as, for instance, at 9, 12, 3, 6, and 9 o'clock.
The pulse is as a rule accelerated and to a rate out of proportion
BABCOCK RH. THE DIAGNOSIS OF PULMONARY TUBERCULOSIS.. JAMA. 1900;XXXV(16):1015-1017. doi:10.1001/jama.1900.24620420029001l