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The experiment of a residence in the most malarious region of the Roman Campagna, using only protection against mosquito bites to ward off the fever, has been a complete success. So far as such a practical test can go, it demonstrates the mosquito theory, which already has been fairly proved in other ways. There are still some who hold to the water-borne theory of malaria, but if there is any basis for such theory it has not been proved on the Campagna, because the same water that was drunk by the malaria afflicted natives was used by the experimenters. The Roman anopheles is apparently only a nocturnal biter, and this is the only weak point in the experiment. If this were the case with all mosquitoes it would be possible for persons to live in every malarial region, but it will probably be found that in some parts the malaria-bearing
THE ROMAN MALARIA EXPERIMENT.. JAMA. 1900;XXXV(18):1160. doi:10.1001/jama.1900.02460440034006