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November 24, 1900


JAMA. 1900;XXXV(21):1352-1353. doi:10.1001/jama.1900.02460470042008

In certain infectious diseases the serum acquires the power of agglutinating the infecting microbe. Applied with practical success in typhoid fever, Arloing, Courmont and others have endeavored to make this test serviceable also in the diagnosis of tuberculosis. A prime requisite for this purpose is homogeneous cultures in which the bacilli are disseminated uniformly, because in cultures on the usual media B. tuberculosis is aggregated into dense masses and clumps. Much work has been given to this end. Arloing and Courmont succeeded quite well by means of cultures on potato soaked in glycerin-water; subcultures on glycerin-bouillon were quite homogeneous, frequent agitation being essential, however, to maintain the even dissemination of the bacilli in the culture-medium. By the action of the serum of tuberculous patients on such cultures the agglutinating reaction has been obtained with a fair degree of constancy. Buard1 reports success in several instances of tuberculosis not otherwise

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