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December 1, 1900


JAMA. 1900;XXXV(22):1412. doi:10.1001/jama.1900.02460480032002

The clinician, both medical and surgical, should ever bear in mind that the human body must be considered as a continuity of structure, removal of any part of which will not be without influence on the remainder. This fact is illustrated, on the one hand, by the assumption of vicarious function, but more especially by the development of certain constitutional phenomena such as have been recognized to follow extirpation or obliterative disease of the ovaries, the thyroid gland, the testicles, etc. These latter effects have been thought to be due to the withdrawal of a suppositious internal secretion, and the theory, while lacking in absolute demonstration, affords a convenient explanation for the results observed. The validity of this view is sustained in part by the important fact of its successful therapeutic application. The control of cretinism and myxedema by means of preparations of the thyroid gland is one of the

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