March 9, 1901


JAMA. 1901;XXXVI(10):672-673. doi:10.1001/jama.1901.02470100064011

Some day, perhaps, we may fully understand the mechanism underlying the determination of sex, but at the present time we must acknowledge the existence of certain deficiencies in this respect. Many hypotheses have been proposed, but no one satisfies all of the conditions, although each may contain some element of truth, and be based on the observation of some actual factor. Even apart from this circumstance, however, it seems probable that the process is not a simple one, but is dependent on a complexity of influences, at least someofwhich have been individually pointed out. On the basis of general knowledge, it seems probable that each parent contributes something in the determination of the sex of the offspring, and it appears likely that the final determining factor must be referred to some peculiarity in nutrition, affecting the spermatozoid, the ovum or the embryo, alone or severally. From this point of view,

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