March 30, 1900


JAMA. 1900;XXXVI(13):895. doi:10.1001/jama.1900.02470130043005

In various inflammatory conditions leucocytes migrate from the vessels in enormous numbers and at the same time there usually is a more or less marked general leucocytosis. Most of the leucocytes in question are of the finely granular variety, with polymorphous nuclei— "polynuclear leucocytes." The mechanism of leucocytosis, which apparently is a very sensitive one, is not thoroughly understood. It is acceded generally that a proliferation must take place in order to account for the great increase in leucocytes in the conditions just mentioned. The exact changes that lie at the bottom of the proliferation are quite hidden as yet. We do not understand the chemical and physical processes set going by the so-called chemotactic substances of various kinds, which induce general leucocytosis and local leucocytic accumulations. This problem is one of fundamental importance, and its ultimate solution depends on other methods of observation than the prevailing morphologic mode of

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