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March 30, 1900


JAMA. 1900;XXXVI(13):897-898. doi:10.1001/jama.1900.02470130045012

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An abstract appears elsewhere in this issue (p. 929) of The Journal giving the details of certain interesting experimental studies by Emmerich and Löw, on the production of immunizing and curative substances. Emmerich and Löw belong to that large school of investigators which believes that acquired immunity and the healing of some infectious diseases are produced by soluble chemical substances of the nature of bacteriolytic enzymes. The source of these substances has been much discussed, some finding it in the serum of the blood and other fluids, others in leukocytic and other cells. Emmerich and Löw, however, claim that these bacteriolytic substances are produced by the bacteria themselves in the same way as it is thought that in cultures injurious substances appear and cause the organisms to die out. These substances are regarded as enzymes formed from zymogens in the bacteria. These enzymes are proteolytic and destroy the bacteria by

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