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Article
April 6, 1901

THE RELATION OF INDICANURIA AND OXALURIA TO GASTRO-INTESTINAL FERMENTATION.

JAMA. 1901;XXXVI(14):956-962. doi:10.1001/jama.1901.52470140026001h
Abstract

The object of treating such a large subject in one article is, if possible, to determine if there is a relationship between the excreted indican and oxalic acid, and the bearing these bodies have on gastro-intestinal fermentations. Harnack1 has shown most conclusively that when oxalic and sulphuric acids are given to dogs per stomach or per os, indicanuria is produced, the sulphuric acid producing not so intense an indican reaction as when oxalic acid is used. He further shows that the subcutaneous injection of even .06 gram of sodium oxalate is followed by indicanuria. He raises the question whether indicanuria is associated with pathologic oxaluria. This is one of the questions which I have tried to solve. The putrefactive bases are formed in the small intestines and are known as indol, skatol and phenol. They are also often spoken of as the aromatic compounds. By the action of the pancreatic

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