In the presence of disease the object of treatment is the repression of the morbid process and the prevention of complications and sequelæ. There are few specifics, the indications for therapeutic measures being in most instances either physiologic or empiric. Notwithstanding the many remedies recommended at different times in the treatment of gonorrhea, silver nitrate still remains one of the best, if not the best, for this purpose. Its use, however, is attended with the disadvantage of being followed by unpleasant burning of such a degree that many patients are fearful of its employment. Inasmuch as argentic albuminate and proteid combinations of nitric acid result from the application, Popper1 was led to make urethral injections of a solution of nitric acid in order to avoid the generation of heat caused by the chemic decomposition of silver nitrate. Cocain or eucain may be added to the solution for anesthetic purposes.
TREATMENT OF GONORRHEA WITH NITRIC ACID.. JAMA. 1901;XXXVII(1):31–32. doi:10.1001/jama.1901.02470270037006