In the present state of knowledge, it is difficult to say to what extent the hemorrhage, spontaneous or otherwise, that occurs in connection with the so-called diseases of the blood, is due to deficient coagulability, and to what extent to changes in the blood-vessels. It would seem, however, that the blood-degeneration occurs first and the vascular disease as a secondary condition. Recent observation has shown that preparations of adrenal gland constitute a most efficient hemostatic, and their activity in this direction has been thought to be due principally to their vasoconstrictor influence. That, over and above this, adrenal gland has also some effect in increasing the coagulability of the blood, would seem to be indicated by its successful employment in the treatment of obstinate epistaxis in a case of hemophilia, as reported by Dr. D. McKenzie.2 A boy, 13 years old, had bleeding from the nose of ten days'
ADRENAL EXTRACT FOR HEMOPHILIA.. JAMA. 1901;XXXVII(3):203. doi:10.1001/jama.1901.02470290049011