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December 21, 1901


JAMA. 1901;XXXVII(25):1682-1683. doi:10.1001/jama.1901.02470510038006

Peripheral neuritis is often associated with autotoxic conditions, as is the case in certain infectious diseases like tuberculosis and diphtheria. As the anatomic changes in the affected nerves are similar in many of these cases it lies near at hand to look for a similar pathogenesis. Reasoning along these lines suggested to Dopter1 to arrange for a series of experiments in which he brought the blood serums from human patients with various diseases directly into contact with the nerve trunks of guinea-pigs. In each case a control experiment was made in the same way with normal serum; in no case did any changes develop in the nerves in the control animals. In the majority of the other experiments there developed the symptoms and the lesions characteristic of peripheral neuritis. The serums of uremic, diabetic, cancerous and other patients, all caused degenerations similar to those produced by Dopter and Lafforgue

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